Exciting changes to Life Extension's website coming soon!

Tuesday, August 25, 2015. Beginning next week, look for a whole new LifeExtension.com!

Life Extension has been hard at work creating a new website that will better reflect who we are and what we have to offer. We've rebuilt our site from the ground up to make your experience at LifeExtension.com more interesting and enjoyable.

Our new website will feature a fresh design and a significantly improved user experience. Reading articles on LifeExtension.com will now be much easier . . . on any device. And you can also look forward to new homepage content that will make it even more rewarding to return to LifeExtension.com often, for the latest Life Extension news and information.

All of these changes have been made in response to your valuable input and requests — and we can't wait to get your feedback!

Be sure to visit LifeExtension.com next week and check it out!

What's Hot

Unfavorable homocysteine, vitamin B12 levels linked with increased risk of lumbar osteoporosis

An article appearing online in the American Journal of Clinical Nutrition on July 29, 2015 reported the outcome of a study of older women which found an increased risk of osteoporosis of the lumbar spine among those with higher levels of methylmalonic acid (MMA, which is elevated in up to 98% of those with vitamin B12 deficiency) and the potentially damaging amino acid homocysteine.

Researchers at the National Institutes of Health utilized information obtained from 2,806 women aged 50 and older who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Whole-body dual-energy X-ray absorptiometry results provided data concerning lumbar spine bone mineral density (BMD). Concurrent blood test results included total homocysteine, red blood cell (RBC) folate, serum vitamin B12, methylmalonic acid and other factors.

Women with normal lumbar spine BMD had lower homocysteine and higher RBC folate than those who had low bone mass or osteoporosis. Elevations in homocysteine and methylmalonic acid were associated with a greater risk of lumbar osteoporosis versus low or normal bone mass. Among those with low serum vitamin B12, the risk of having a total body BMD that was among the lowest 25% of participants was significantly greater than the risk experienced by the remainder of the subjects.

"Our analysis suggests that elevated homocysteine and MMA are significantly associated with increased likelihood of osteoporosis in a nationally representative sample of US women," Regan L. Bailey and colleagues conclude. "Given the public health burden of osteoporosis and age-related bone disorders together with the rapidly aging US population, we hope this work will serve to stimulate additional research aimed at addressing the role of vitamin B12 and folate in bone health in older women in the United States."

Life Extension Clinical Research Update
Effects of Nutritional Supplements on Cognition, Mood, and Fatigue

Life Extension is sponsoring a study to assess the effects of nutritional supplements in support of cognition, mood and fatigue in individuals with memory complaints, an altered mood and/or feelings of fatigue within the past six months.

If you or someone you know is:

Between 40-70 years of age
Normal weight to overweight (BMI 18.5–29.9)
In good health
Experiencing memory complaints, an altered mood, and/or feelings of fatigue (within the past six months)
Currently drinking no more than one cup of coffee a day
Able to comply with all study procedures and visits

Qualified participants will receive at no cost during the trial:

Study product
Blood tests
Blood pressure evaluations
Up to $250 for time and travel expenses
A $50 referral bonus is also available.*

Please call 1-866-517-4536 for further information and to see if you qualify.

*If you refer someone who enrolls in a study and completes their final visit with closeout procedures, you will be compensated the amount noted for the study.

https://www.lifeextension.com/clinicalresearch/ClinicalTrials.htm

Health Concern

Osteoporosis

Osteoporosis, defined as a reduction of bone mass or bone density, was long viewed as a disease unique to aging women, and has been treated primarily with conjugated equine estrogens (CEE) in hopes of mitigating the decline in endogenous female hormone levels that occurs during menopause (Leong 1998, Wylie 2010). Sadly, much of what conventional wisdom held true about osteoporosis turns out to be flawed; it is now clear that osteoporosis (like many age-related conditions) is not a disease with a singular cause affecting a specific population. Rather, it is a multi-faceted disease driven by a barrage of interrelated factors, and must be addressed as such for optimal prevention and treatment (Clarke 2010).

Today we realize that osteoporosis not only impacts the lives of women, but of men as well; fully one third of those affected by the condition are males (about 2.8 million of them as of 2011), and that number is likely to grow as the population ages (Cawthon 2011, Kawate 2010, Nuti 2010).

Scientific advancements have revealed that the etiology of osteoporosis stems not only from hormonal imbalances, but oxidative stress, elevated blood sugar, inflammation, and components of the metabolic syndrome as well (Clarke 2010, Confavreux 2009, Lieben 2009; Zhou 2011).

Overlooked by mainstream medicine is the critical role that micronutrients play in bone health. For instance, emergent research on vitamin K has attracted great scientific interest through the revelation of its involvement, along with vitamin D, in both bone health and atherosclerosis, a condition to which osteoporosis is intimately related (Baldini 2005, Abedin 2004). In fact, these two conditions can be thought of as mirror images of one another (McFarlane 2004, D'Amelio 2009).

Latest Products

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Glycomark® values above 14 are considered ideal. A value of 10 is considered "good". Anything lower is a sign of frequent blood sugar spikes, which is dangerous to your health. If your Glycomark® is 14, it means you achieved a HbA1C of 7.0 without lots of highs and lows. If your Glycomark® is 2, then you have had lots of spikes and crashes to get that average. The ideal combination of glycemic control is a good HbA1c with a high Glycomark®.

Diabetic or not, controlling your blood sugar may help you have more energy, lose weight, improve your immune function and reduce future complications from dangerous blood sugar spikes.

Glycomark® is on sale until September 7, 2015 for only $74.25.

Disease Prevention and Treatment—Hardcover or eBook

Item #DPT05

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Stay healthier longer with the hardcover or digital version of Disease Prevention and Treatment (5th ed). It's your ultimate medical reference guide, backed by nearly 17,000 references to the scientific literature.

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Within Disease Prevention and Treatment, you'll find the latest evidence-based protocols for managing 130 different health concerns - from cancer and cardiovascular disease to arthritis and neurological disorders. All documented by thousands of published studies from prestigious scientific journals. You'll also learn how to use natural compounds, hormones, novel pharmaceutical agents, and preventive blood testing to complement mainstream therapies and live a long, healthy life. No other book on the market does all this!