Tuesday, March 15, 2016

An article published online on February 10, 2016 in the American Journal of Clinical Nutrition reports an association between a higher Dietary Inflammatory Index (DII) score and a significantly increased risk of mortality from cardiovascular disease and cancer over a median of 12.4 years. 

The current investigation included 8,089 men and women enrolled in the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) study which compared the effects of a placebo to supplementation with ascorbic acid, vitamin E, beta-carotene, selenium, and zinc from 1994 to 2002. Participants' dietary records were utilized to calculate each subject's Dietary Inflammatory Index score, which rates total calories, carbohydrates and other components as proinflammatory, and such items as monounsaturated and polyunsaturated fatty acids, vitamins, and other nutrients as anti-inflammatory factors.

Over a 12.4 year median, 41 deaths caused by cardiovascular disease, 123 cancer deaths and 43 deaths due to other causes occurred. Participants whose Dietary Inflammatory Index scores were among the top one-third of subjects had a risk of dying from cancer or cardiovascular disease that was 53% higher than those whose scores were among the lowest third. For cancer alone, the risk of death was 83% higher in the highest DII group. Subjects in the placebo group whose scores were among the top third had over twice the risk of death from all causes over follow-up compared to those whose scores were among the lowest third, however this effect was not observed among those who received antioxidant supplements.

"To our knowledge, this study was the first to investigate the prospective association between the DII and mortality in a large population-based French cohort including both men and women," authors Laurie Graffouillère and colleagues announce. "In line with results from laboratory studies, our findings suggest that antioxidants may contribute to counteract some of the potential deleterious effects of a proinflammatory diet on mortality."

Life Extension is sponsoring a study to assess the effects of nutritional supplements in support of cognition, mood and fatigue in individuals with memory complaints, an altered mood and/or feelings of fatigue within the past six months.

To qualify:

• Between 40-70 years of age
• Normal weight to overweight (BMI 18.5—29.9)
• In good health
• Experiencing memory complaints, an altered mood, and/or feelings of fatigue (within the past six months)
• Currently drinking no more than one cup of coffee a day
• Able to comply with all study procedures and visits

Qualified participants will receive at no cost:

• Study product
• Blood tests
• Blood pressure evaluations
• Up to $250 for time and travel expenses
• A $50 referral bonus is also available.*

Please call 1-866-517-4536 for further information and to see if you qualify.
https://www.lifeextension.com/clinicalresearch/ClinicalTrials.htm

*If you refer someone who enrolls in a study and completes their final visit with closeout procedures, you will be compensated the amount noted for the study.

Highlight

Save up to 70% during Life Extension's Overstock Sale!

Stock up on premium quality formulations at below wholesale prices.

Venotone, 60 capsules Promotes healthy fluid balance Item #00408 Add to Cart Sale Price: $5.68 Retail $18.95	Super-Absorbable CoQ10 Ubiquinone with d-Limonene, 100 mg, 100 softgels Promotes healthy brain function Item #00950 Add to Cart Sale Price: $18.40 Retail $46.00
Pomegranate Fruit extract, 30 vegetarian capsules Heart-healthy, full spectrum pomegranate Item #00956 Add to Cart Sale Price: $6.82 Retail $19.50	Mega Lycopene, 15 mg, 90 softgels Supports prostate and arterial health Item #00455 Add to Cart Sale Price: $14.00 Retail $35.00
Glucosamine/ Chondroitin Capsules, 100 capsules High quality nutrition for healthy joints and cartilage Item #00522 Add to Cart Sale Price: $15.20 Retail $38.00	Lifting and Tightening Complex, 1 oz. Get the lift you're looking for Item #80103 Add to Cart Sale Price: $22.35 Retail $74.50

Health Concern

Inflammation (Chronic)

A diet high in saturated fat is associated with higher pro-inflammatory markers, particularly in diabetic or overweight individuals (Nappo et al. 2002) (Peairs et al. 2011). This effect was absent in healthy individuals (Myhrstad et al. 2011, Poppitt et al. 2008, Payette et al. 2009). Diets high in synthetic trans-fats (such as those produced by hydrogenation) have been associated with increases in inflammatory markers (IL-6, TNF-α, IL-8, CRP) in some studies (Mozaffarian et al. 2004) (Lopez-Garcia et al. 2005), but had no effect in others (Nielsen et al. 2011, Bendsen et al. 2011). The increases in markers of inflammation due to synthetic trans-fats may be more pronounced in individuals that are also overweight (Nielsen et al. 2011).

General dietary over-consumption is a major contributor to inflammation and other detrimental age-related processes in the modern world. Therefore, eating a calorie-restricted diet is an effective means of relieving physiologic stressors. Indeed, several studies show that calorie restriction provides powerful protection against inflammation (Ahmadi 2011; González 2012).

As an aging human, you face a daily onslaught of excess glucose that poses a grave risk to your health and longevity. Surplus glucose relentlessly reacts with your body's proteins, causing damaging glycation reactions while fueling the fires of chronic inflammation and inciting the production of destructive free radicals (Basta 2004; Uribarri 2005; Toma 2009).

Latest Products