Tuesday, July 28, 2015. The February 2015 issue of the journal Obesity reported the outcome of a double-blind trial which found a benefit for alpha-lipoic acid and the omega 3 fatty acid eicosapentaenoic acid (EPA) in overweight and obese women.

The trial included 77 overweight women between the ages of 20 and 50 years who were following a reduced calorie diet. Participants received capsules containing a placebo or 1300 milligrams (mg) EPA, 300 mg alpha-lipoic acid, or 1300 mg EPA plus 300 mg alpha-lipoic acid daily for ten weeks. All supplements were consumed in divided doses to help reduce the impact of plasma level decline after oral supplementation. Weight, body composition, leptin levels and other factors were evaluated before and after the treatment period.

While all groups lost weight by the end of the trial, women who received alpha-lipoic acid (with or without EPA) experienced a significantly greater reduction in body weight, hip circumference and fat mass in comparison with the other groups. EPA supplementation was associated with a moderate decrease in waist to hip ratio as well as a reduction in the decline in resting metabolic rate that normally occurs with weight loss which the authors suggest may be attributable to the concomitant reduction in leptin decline observed in the EPA group. They remark that EPA's effect on leptin suggests that supplementation with the fatty acid could become useful for weight loss maintenance.

"Our data suggest that alpha-lipoic acid supplementation at a dose of 300 mg/day combined with an energy-restricted diet might help to promote weight loss and fat mass reduction in healthy obese women," authors Ana E. Huerta and colleagues conclude. "Although EPA supplementation did not have any additional effect on the reduction of body and fat mass, it prevents the fall of leptin during weight loss. It is essential that these observations be further explored and the underlying mechanisms better elucidated."

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Hormone Blood testing for a healthier, stronger, more energetic YOU!
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