Newsletter

Newsletter

Vitamin C supplementation could provide exercise benefit

Tuesday, October 6, 2015

The 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics held in Savannah, Georgia last month was the site of a presentation of the finding of a cardiovascular benefit for supplementing with vitamin C similar to that elicited by exercise in overweight and obese adults. The discovery could be of benefit for those who fail to engage in recommended physical activities on a regular basis, as is the case with over half of those who are overweight or obese.

Blood vessels in those who are overweight and obese exhibit increased activity of endothelin (ET)-1, a small vessel-constricting protein. Higher levels increase the susceptibility of the vessels to constriction, which affects blood flow and elevates the risk of vascular disease. Although exercise is known to reduce ET-1 activity, many individuals find it challenging to find time for it in their busy schedules, or have physical limitations that reduce their ability to participate.

Postdoctoral research fellow Caitlin Dow, PhD, and colleagues at the University of Colorado compared a regular walking program to the effects of 500 milligrams timed-release vitamin C per day in 35 sedentary, overweight or obese men and women for three months. They determined that supplementing with the vitamin decreased vasoconstriction due to endogenous ET-1 activity as much as walking does.

 
What's Hot
Meta-analysis concludes that supplementing with vitamin C is associated with lower blood pressure
What's Hot  
 

In a review published on April 4, 2012 in the American Journal of Clinical Nutrition, researchers from Johns Hopkins in Baltimore report a reduction in systolic and diastolic blood pressure associated with vitamin C supplementation.

For their analysis, Edgar R. Miller III and his colleagues selected 29 randomized clinical trials conducted between 1996 and 2011 that involved the oral administration of vitamin C for at least two weeks. Average pretreatment systolic blood pressure ranged from 117 to 175 mmHg, and diastolic from 73 to 97 mmHg. The dose of vitamin C used in the studies varied from 60 to 4000 milligrams per day, with a median dose of 500 milligrams daily.

In a pooled analysis of the trials' participants, vitamin C supplementation was associated with a 3.84 mmHg reduction in systolic blood pressure and a 1.48 mmHg reduction in diastolic pressure. When trials involving patients with hypertension were analyzed, reductions averaged 4.85 mmHg and 1.67 mmHg. Mechanisms posited for vitamin C in reducing blood pressure include an increase in a cofactor for endothelial nitric oxide synthase (which increases the production of nitric oxide), and improvement of endothelial function of brachial and coronary arteries.

"This meta-analysis is the first quantitative review of randomized trials evaluating the effect of vitamin C supplementation on blood pressure," the authors announce. "In short-term trials, vitamin C supplementation reduced systolic blood pressure and diastolic blood pressure. Long-term trials on the effects of vitamin C supplementation on blood pressure and clinical events are needed."

 
Life Extension Clinical Research Update

Interested in participating in future studies?

Play an important role in the research process.

Be among the first to potentially benefit from cutting-edge therapies, including innovative nutritional approaches, that may improve your quality and length of life.

By participating in a study, you may also receive:

  • Blood tests
  • Blood pressure checks
  • Dietary supplements
  • Study product
  • Gift cards
  • Compensation for time and travel

Make a difference for yourself or someone else now.
Register For Upcoming Clinical Trials
Or Call For Details: 1-866-517-4536

Register Now

https://www.lifeextension.com/clinicalresearch/ClinicalTrials.htm

Health Concern

Atherosclerosis and cardiovascular disease

The cause and progression of vascular disease is intimately related to the health of the inner arterial wall. Blood vessels are composed of three layers. The outer layer is mostly connective tissue and provides structure to the layers beneath. The middle layer is smooth muscle; it contracts and dilates to control blood flow and maintain blood pressure. The inner lining consists of a thin layer of endothelial cells (the endothelium), which provides a smooth, protective surface. Endothelial cells prevent toxic, blood-borne substances from penetrating the smooth muscle of the blood vessel.

However, as we age, a barrage of atherogenic factors, if left unchecked, damages the delicate endothelial cells. This damage leads to endothelial dysfunction and ultimately allows lipids and toxins to penetrate the endothelial layer and enter the smooth muscle cells. This results in the initiation of an oxidative and inflammatory cascade that culminates in the development of plaque deposits.

Vitamin C inhibits damage caused by oxidative stress. In cigarette smokers, daily supplementation with 500 mg vitamin C significantly decreased the appearance of oxidative stress markers (Dietrich M et al 2002). Another study showed that supplementation with 500 mg vitamin C and 400 IU vitamin E daily reduced the development of accelerated coronary arteriosclerosis following cardiac transplantation (Fang JC et al 2002).

Vitamin C's benefits seem especially profound in people who suffer from both diabetes and coronary artery disease. One study demonstrated that, in this group, vitamin C significantly improved vasodilation (Antoniades C et al 2004).

Read More
 

Latest Products

Healthy Aging Panel – Basic

Healthy Aging Panel Basic

Item #LC100025
Add to Cart

Malnutrition places Americans at risk for serious health consequences. For people with chronic conditions, proper nutrition is more than just a good idea. It's an essential part of managing health concerns such as diabetes, heart disease, high blood pressure, osteoporosis, cancer and more.

Many people think malnutrition refers only to people who are undernourished and appear emaciated. However, malnutrition is actually a broad term defined as the insufficient, excessive or imbalanced consumption of nutrients — and yes, many people in the US are malnourished even though they appear overweight!

Consuming the wrong types of foods — foods that are calorie dense, but nutritionally poor contribute to this phenomenon known as "hidden hunger," a serious and growing challenge in the US. Officially known as micronutrient deficiency, people fail to obtain essential nutrients such as vitamins, minerals and trace elements which allow them to be mentally and physically healthy.

Are you experiencing loss of muscle tone or energy, a declining immune system, depression or depleted memory? If you're overweight you certainly need to be concerned since "hidden hunger" and obesity are often highly correlated. Doesn't it make sense to protect yourself with a Healthy Aging Panel so you can know if you're deficient in key nutrients?

The Healthy Aging Panel (basic) contains the following components:

  • Complete Metabolic Panel with Lipids – To detect proteins, anemia, electrolytes and kidney and liver function.
  • Complete Blood Count (CBC) – To evaluate anemia, immune function and infection.
  • C-Reactive Protein (high sensitivity)- Malnutrition may aggravate existing inflammation.
  • Vitamin B12- Vitamin B12 deficiencies can lead to anemia, depression, dementia and neurological damage
  • Folate – Folate deficiencies can lead to anemia, irritability, and birth defects if pregnant.
  • Vitamin D 25-hydroxy - The consequences of Vitamin D deficiency are numerous and include skeletal diseases, metabolic disorders, cancer, cardiovascular disease, autoimmune diseases, infections, cognitive disorders and more.
  • Hemoglobin A1C (HbA1C) - Keeps an eye on how well you're keeping your diet free of sugar which damages DNA and contributes to "hidden hunger".
  • Thyroid Stimulating Hormone (TSH)-Deficiency of vitamins and minerals can lead to low thyroid function.
  • Ferritin- A protein which serves as a storage form of iron. Low values may indicate iron deficiency anemia
  • Insulin- Optimal levels show the balance of what type of food you eat, when you eat it and your activity level.

 

Product2Name}}

Skin-Restoring Phytoceramides with Lipowheat®,
30 liquid vegetarian capsules

Item #01596
Add to Cart

Skin Restoring Phytoceramides with Lipowheat® offers the skin-nourishing benefits of wheat-derived ceramide oils in a convenient oral supplement designed to support dermal elasticity, proper hydration, and lasting comfort.

Benefits at a Glance

  • Concentrated oral formula for youthful-looking skin
  • Promotes healthy skin hydration and comfort
  • Encourages healthy ceramide levels in aging skin
  • Addresses the challenge of poor ceramide absorption

Enjoy ageless, healthy-looking skin and replace the ceramides you lose as you age with Skin Restoring Phytoceramides with Lipowheat® - only from Life Extension®!

Lipowheat® is a registered trademark of Arco, Robertet Group, France.

Related Life Extension Magazine® Articles
Enhance Your Endothelial Function

  Is Conventional Pomegranate Extract Enough?
Life Extension Magazine   Life Extension Magazine