Life Extension Supports Nutritional Research In Chronic Kidney Disease

Life Extension® supports nutritional research in chronic kidney disease

Tuesday, July 17, 2012. In a study supported by Life Extension, recognized by the National Kidney Foundation, and published in Journal of Renal Nutrition, researchers at Baylor University in Texas evaluated the effects of fish oil ingestion in thirty-one patients with chronic kidney disease (CKD).

An important consideration in chronic kidney disease, a leading cause of disability in the United States, is excess production of proinflammatory factors called cytokines. These inflammatory factors are implicated in a variety of health conditions, including cardiovascular and joint health, as well as kidney health. Although numerous studies support the health benefits of the omega-3 fatty acids EPA and DHA found naturally in fish oil, the potential effects of supplementation with fish oil in chronic kidney disease have not been well characterized in the scientific literature.

The Baylor scientists conducted a double-blind, randomized, placebo-controlled trial in non-dialysis chronic kidney disease patients to evaluate a nutritional supplement vs. placebo upon a variety of proinflammatory parameters. The cytokines evaluated in the study included interleukin 1b (IL-1b) and interleukin 6 (IL-6). The active treatment group received fish oil containing 1,400 mg of EPA and 1,000 mg of DHA daily, along with olive fruit extract (600 mg daily), and sesame lignans (20 mg daily).

The researchers discovered that fish oil, olive fruit extract, and sesame lignans had a significant, beneficial effect upon the inflammatory cytokine IL-1b compared with placebo, with lower levels in the active treatment group. Interleukin-6 levels did not change significantly in chronic kidney disease patients during the short trial.

Future research to include larger numbers of patients as well as longer duration trials will help clarify the effects of nutritional supplementation upon inflammatory factors in chronic kidney disease over time.

Vitamin B6 deficiency associated with inflammation

In a study described online on May 23, 2012 in the Journal of Nutrition, researchers at Tufts University in Boston report a relationship between low levels of plasma pyridoxal-5'-phosphate (PLP), which indicate reduced levels of vitamin B6, with an increase in markers of inflammation.

"Low vitamin B6 status, based on plasma concentrations of pyridoxal-5-phosphate, has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes," write Lydia Sakakeeny of Tufts Jean Mayer USDA Human Nutrition Research Center and her colleagues. "Our objective was to examine the association between plasma PLP and multiple markers of inflammation in a community based cohort."

The current study included 2229 men and women enrolled in the Framingham Offspring study, who were recruited in 1971 and have undergone periodic examinations thereafter. Blood drawn between 1998 and 2001 was analyzed for plasma PLP and 13 markers of inflammation, including C-reactive protein, fibrinogen, interluekin-6, tumor necrosis factor-alpha and other factors.

The researchers created inflammation scores based on the values of each inflammatory marker. An inverse relationship was observed between high inflammation scores and low levels of PLP. The authors note that decreased plasma PLP levels may reflect mobilization of PLP into inflammatory sites and that a causative relationship between reduced vitamin B6 levels and inflammation cannot be determined. However, they conclude that "This study in combination with past findings further supports our hypothesis that inflammation is associated with a functional deficiency of vitamin B6."

Free Webinar

Boosting Brain Power Naturally

Hosted by Michael A. Smith, M.D.

Wednesday, July 25, 2012
7 PM—8 PM ET

Don't miss this exciting new webinar. Dr Smith will highlight scientifically proven nutrients for boosting brain power. If memory, recall and mental fatigue are things you're dealing with, you won't want to miss this presentation.

Dr Smith will be a recurring guest on Suzanne Somers' new TV show airing this fall on the Lifetime network. Stay tuned for more details!

Michael A. Smith, M.D.

Reserve your webinar seat now at: https://www2.gotomeeting.com/
register/436514330

After registering, you will receive a confirmation e-mail containing information about joining the webinar.

System requirements PC-based attendees Required: Windows® 7, Vista, XP or 2003 Server
Macintosh®-based attendees Required: Mac OS® X 10.5 or newer

Visit www.lifeextension.com/health-basics/podcasts-video-media to view past webinars!

Latest Supplements

CoffeeGenic™ Green Coffee Extract with Glucose Control Complex†
90 vegetarian capsules
Item #01607

CoffeeGenic™ Green Coffee Extract with Glucose Control Complex is a multi-nutrient formulation comprised of five cutting-edge ingredients that help support healthy blood glucose levels already within normal range.

In addition to the chlorogenic acid in CoffeeGenic™ Green Coffee Extract, which favorably modulates after-meal glucose levels to limit dangerous glucose surges, this formula also includes:

Iodine, a trace element involved in the production of thyroid hormones, is primarily responsible for regulating metabolism . . . thereby promoting healthy glucose absorption into cells where it is used to produce energy.
Crominex® 3+ complex (chromium optimized with standardized extract of Indian gooseberry and a proprietary form of an adaptogen called shilajit) supports healthy cellular glucose utilization.
InSea2® (a proprietary form of seaweed extract) blocks the action of the glucosidase and amylase enzymes used to break down carbohydrates into glucose.
Integra-Lean® Irvingia African Mango extract helps slow the rate of carbohydrate absorption from the intestines.
Green tea extract supports healthy body weight.

†This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Pycnogenol® 100 milligrams, 60 vegetarian capsules
Item #01637

Life Extension® Pycnogenol® French Maritime Pine Bark Extract is a natural plant extract containing procyanidins, bioflavonoids, and other health-giving molecules that synergistically support the body's natural defenses against five major processes that characterize premature aging. Its effectiveness is backed by 40 years of study. Life Extension® Pycnogenol® French Maritime Pine Bark Extract is designed to counteract premature-aging-related changes by providing support for the following mechanisms:

Membrane function: Pycnogenol® promotes the integrity and normal characteristics of cell membranes.
DNA function: Pycnogenol® helps support normal DNA function through antioxidant activity and possibly other mechanisms.
Easing inflammation: Pycnogenol® helps ease inflammation by normal modulation of inflammatory cytokine molecules.
Oxidative stress: Pycnogenol® supports the normal functioning of healthy antioxidant systems to help suppress free radicals and protect DNA.
Glycation: Pycnogenol® supports cellular metabolism of sugar, healthy fasting, and post-meal blood sugar levels already within normal range, and normal sugar absorption in the intestine.

Highlight

Life Extension Update		What's Hot
	Mechanism found for omega-3 fatty acids in reducing insulin resistance and inflammation		Fish oil supplementation may benefit dialysis patients
	Vitamin D treatment in kidney disease cuts deaths by one-fourth		Improved dietary fatty acids alter gene expression to reduce inflammation
	Fatty fish consumption associated with reduced kidney cancer risk		Fish oil may benefit individuals with kidney disease

Life Extension Magazine®		Health Topics
	Innovative strategies to combat kidney disease		Chronic inflammation
	The purest EPA-DHA fish oil in the world		Chronic kidney disease
	Why you need more omega-3 fatty acids		Kidney health

shadow

Pycnogenol® is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents. Supported by over 40 years of research.

Integra-Lean® Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. InSea2® is a registered trademark of innoVactiv™. Crominex® 3+ is a registered trademark of Natreon, Inc.