Life Extension Magazine®
Every day, your eyes are bombarded by various harmful biologic and environmental factors.
Ultraviolet light, oxidative stress, and high blood sugar are among the most damaging causes of premature ocular disorders.1
Two carotenoid pigments, lutein, and zeaxanthin, protect eye tissues from multiple types of injury.2-6
Humans cannot make carotenoids.7 Modern diets don't always provide enough for optimal protection.8,9
The importance of lutein and zeaxanthin cannot be overlooked.
They are capable of guarding against drivers of age-related visual loss, including macular degeneration, diabetic retinopathy, cataracts, and glaucoma.10-14
Intake of abundant amounts of a range of carotenoids is one of the healthiest proactive steps you can take to maintain vision.
Support Healthy Vision
Eyes actively take up lutein and zeaxanthin, concentrating these carotenoids in the retina and other ocular areas.15-18
Carotenoids serve multiple purposes. For one, they filter out potentially harmful wavelengths of light, capturing their energy and safely dissipating it.2-6
Light rays are a form of electromagnetic radiation that can inflict significant damage.
Lutein and zeaxanthin protect against the oxidative damage and inflammation that contribute to chronic eye disease, including cataracts and macular degeneration.19,20
Oral intake of lutein and zeaxanthin has been shown to boost their content in the eyes, protecting against common age-related disorders that cause vision loss.
Age-Related Macular Degeneration
The macula is the most important part of the retina. It is where most photoreceptors reside and is responsible for crisp, high-resolution vision.
When consumed in adequate amounts, lutein and zeaxanthin build an effective barrier in a layer of the retina called the retinal pigment epithelium. There they help filter out harmful ultraviolet light while reducing oxidative stress and inflammation.
These effects may help prevent the development of macular degeneration.
One study conducted over more than 20 years found that people with the highest intake of lutein and zeaxanthin have a stunning 41% lower risk of advanced macular degeneration.21
In clinical studies, older adults who already have macular degeneration, taking lutein and zeaxanthin has been shown to slow its progression and improve visual function, including:11,16,17,22,23
- Reducing nighttime glare,
- Improving visual contrast, and
- Boosting visual acuity (sharpness).
Poor night vision is a common early warning sign of macular degeneration.24 In a clinical trial of older adults with poor night vision, daily intake of a lutein-zeaxanthin blend improved multiple markers of nighttime visual function.25
Cataracts
Cataract is the clouding of the lens that is common in older individuals. Diabetes, smoking and ultraviolet rays from sunlight exposure are also associated with cataract formation.26 This impedes vision and is the leading cause of vision loss in the United States.27
Carotenoids can filter out harmful light in the lens. Studies have found that individuals with a higher intake of lutein have lower rates of cataracts.13
Glaucoma
Glaucoma can damage the optic nerve, leading to vision loss and blindness in older adults. It is an abnormality of the drainage system of the eyes that causes excess pressure in the eyes due to fluid retention.
A higher dietary intake of carotenoids, including lutein and zeaxanthin, is associated with a lower risk of glaucoma.
In human studies a protective trend was observed in individuals consuming higher dietary carotenoids who had lower risk of glaucoma.14 In clinical studies of glaucoma patients, oral intake of carotenoids helps protect against the progression of vision loss and improves visual performance.14,28,29
What You Need to Know
Lutein and Zeaxanthin Guard Against Eye Damage
- Oxidative stress, elevated blood sugar, and ultraviolet light from the sun can damage the eyes.
- With increasing age, damage from these factors accumulates and can lead to eye disease and vision loss.
- Carotenoid pigments can protect against these factors. They can only be obtained through diet or direct oral intake.
- Studies show that higher intake of the carotenoids lutein and zeaxanthin improves visual function and helps reduce the development and progression of macular degeneration, cataracts, glaucoma, and other disorders.
Diabetic Eye Disease
Diabetic retinopathy, eye disease resulting from poor blood glucose control, has become one of the most common causes of vision loss.
Patients with diabetic eye disease typically have lower levels of lutein and zeaxanthin than healthy adults. In these patients, taking carotenoids improves visual function, boosting visual clarity and contrast.14,30
Digital Eye Strain
LED lights and screens emit much more harmful blue light than natural sunlight.31
While most eye damage accumulates over time, chronic long exposure to digital screens can also cause short-term symptoms known as digital eye strain.32
These symptoms may include blurred vision, headaches, dry eyes, neck, shoulder, and back pain. An estimated 6 out of 10 people in the U.S. suffer from some of these symptoms.32
Lutein and zeaxanthin act as a blue light filter in the eyes, safely absorbing the wavelengths associated with long hours spent looking at digital displays.3-5
Summary
Oral intake of carotenoids can help reduce the risk of long-term vision loss and eye disease, and protect the eyes from modern digital eye strain.
Free radical stress, high blood sugar, and ultraviolet light damage eye tissues and can lead to vision loss.
Consumed orally, the carotenoids lutein and zeaxanthin are taken up by eye tissues to act as shields against these damaging factors.
Studies show that increasing levels of these carotenoids can improve visual function while defending against the development and progression of macular degeneration, cataracts, glaucoma, and other eye diseases.
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialists at 1-866-864-3027.
Other Compounds That Promote Eye Health
Other nutrients can support eye health, including:
Astaxanthin, a carotenoid responsible for the reddish-pink coloration of salmon, flamingos, and crustaceans. It has been found to have protective effects in the eyes and may help prevent the progression of eye disease.33,34
Saffron, a spice that has been used for centuries if not longer, for various ailments. It improves visual function and can help improve symptoms of macular degeneration.35,36
References
- Available at: https://www.cdc.gov/visionhealth/basics/ced/index.html. Accessed January 19, 2024.
- Bian Q, Gao S, Zhou J, et al. Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med. 2012 Sep 15;53(6):1298-307.
- Johra FT, Bepari AK, Bristy AT, Reza HM. A Mechanistic Review of beta-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease. Antioxidants (Basel). 2020 Oct 26;9(11).
- Kijlstra A, Tian Y, Kelly ER, Berendschot TT. Lutein: more than just a filter for blue light. Prog Retin Eye Res. 2012 Jul;31(4):303-15.
- Loskutova E, Nolan J, Howard A, Beatty S. Macular pigment and its contribution to vision. Nutrients. 2013 May 29;5(6):1962-9.
- Xue C, Rosen R, Jordan A, Hu DN. Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies? J Ophthalmol. 2015;2015:523027.
- Eggersdorfer M, Wyss A. Carotenoids in human nutrition and health. Arch Biochem Biophys. 2018 Aug 15;652:18-26.
- Bohm V, Lietz G, Olmedilla-Alonso B, et al. From carotenoid intake to carotenoid blood and tissue concentrations - implications for dietary intake recommendations. Nutr Rev. 2021 Apr 7;79(5):544-73.
- Stringham JM, Stringham NT. Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation. Exp Eye Res. 2016 Oct;151:1-8.
- Agron E, Mares J, Clemons TE, et al. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2. Ophthalmology. 2021 Mar;128(3):425-42.
- Lem DW, Davey PG, Gierhart DL, Rosen RB. A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration. Antioxidants (Basel). 2021 Aug 5;10(8).
- Ma L, Hao ZX, Liu RR, et al. A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract. Graefes Arch Clin Exp Ophthalmol. 2014 Jan;252(1):63-70.
- Manayi A, Abdollahi M, Raman T, et al. Lutein and cataract: from bench to bedside. Crit Rev Biotechnol. 2016Oct;36(5):829-39.
- Lem DW, Gierhart DL, Davey PG. A Systematic Review of Carotenoids in the Management of Diabetic Retinopathy. Nutrients. 2021 Jul 16;13(7).
- Harrison EH. Mechanisms of Transport and Delivery of Vitamin A and Carotenoids to the Retinal Pigment Epithelium. Mol Nutr Food Res. 2019 Aug;63(15):e1801046.
- Huang YM, Dou HL, Huang FF, et al. Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degeneration. Biomed Res Int. 2015;2015:564738.
- Huang YM, Dou HL, Huang FF, et al. Changes following supplementation with lutein and zeaxanthin in retinal function in eyes with early age-related macular degeneration: a randomised, double-blind, placebo-controlled trial. Br J Ophthalmol. 2015 Mar;99(3):371-5.
- Stringham JM, O'Brien KJ, Stringham NT. Macular carotenoid supplementation improves disability glare performance and dynamics of photostress recovery. Eye Vis (Lond). 2016;3:30.
- Pelletier AL, Rojas-Roldan L, Coffin J. Vision Loss in Older Adults. Am Fam Physician. 2016 Aug 1;94(3):219-26.
- Liu XH, Yu RB, Liu R, et al. Association between lutein and zeaxanthin status and the risk of cataract: a meta-analysis. Nutrients. 2014Jan 22;6(1):452-65.
- Wu J, Cho E, Willett WC, et al. Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up. JAMA Ophthalmol. 2015 Dec;133(12):1415-24.
- Akuffo KO, Nolan JM, Howard AN, et al. Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye (Lond). 2015 Jul;29(7):902-12.
- Ma L, Dou HL, Huang YM, et al. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. Am J Ophthalmol. 2012 Oct;154(4):625-34 e1.
- Ying GS, Maguire MG, Liu C, et al. Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. Ophthalmology. 2008 Nov;115(11):1876-82.
- Richer S, Novil S, Gullett T, et al. Night Vision and Carotenoids (NVC): A Randomized Placebo Controlled Clinical Trial on Effects of Carotenoid Supplementation on Night Vision in Older Adults. Nutrients. 2021 Sep 14;13(9).
- Available at: https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/cataracts/causes-cataracts. Accessed January 16, 2024.
- Available at: https://www.cdc.gov/visionhealth/basics/ced/index.html. Accessed 01/11/2023,
- Hunter AML, Loskutova E, Lingham G, et al. Higher Macular Pigment Levels are Associated with Better Contrast Sensitivity and Photostress Recovery Time in Patients with Open-Angle Glaucoma Supplemented with Carotenoids. Investigative Ophthalmology & Visual Science. 2022;63(7):2699 – A0063-2699 – A0063.
- Loughman J, Loskutova E, Butler JS, et al. Macular Pigment Response to Lutein, Zeaxanthin, and Meso-zeaxanthin Supplementation in Open-Angle Glaucoma: A Randomized Controlled Trial. Ophthalmol Sci. 2021 Sep;1(3):100039.
- Hu BJ, Hu YN, Lin S, et al. Application of Lutein and Zeaxanthin in nonproliferative diabetic retinopathy. Int J Ophthalmol. 2011;4(3):303-6.
- Available at: https://www.reviewsce.com/ce/the-lowdown-on-blue-light-good-vs-bad-and-its-connection-to-amd-109744. Accessed January 22, 2024.
- Available at: https://thevisioncouncil.org/blog/vision-council-shines-light-protecting-sight-and-health-multi-screen-era. Accessed April 22, 2022,
- Cort A, Ozturk N, Akpinar D, et al. Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure. Regul Toxicol Pharmacol. 2010 Oct;58(1):121-30.
- Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011 Dec;16(4):355-64.
- Fernandez-Albarral JA, de Hoz R, Ramirez AI, et al. Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases. Neural Regen Res. 2020 Aug;15(8):1408-16.
- Heitmar R, Brown J, Kyrou I. Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies. Nutrients. 2019 Mar 18;11(3).