Life Extension Magazine®

Take blood tests to  indentify the risks the body may have for heart attack or stroke

As We See It: Confirming What Was Discovered Decades Ago

Studies confirm that excess sodium and insufficient potassium increases cardiovascular risk. Life Extension® advocates for at-home blood pressure monitoring and comprehensive blood tests to identify risks before a cardiovascular event occurs.

By William Faloon.

William Faloon
William Faloon

It was not until 1912 that a cardiologist established that the narrowing of coronary arteries could cause chest pain (angina).1

Doctors today continue to debate the triggers of atherosclerosis that cause most heart attacks.

Research dating back many decades associates' diets high in sodium and low in potassium with increased cardiovascular risk.2-10

A study published in 2017 found that people with high sodium and low potassium dietary intake are 60% more likely to suffer an ischemic stroke.11

This finding was supported in 2022 by a study published in the New England Journal of Medicine that assessed sodium and potassium urinary excretion as a biomarker for sodium-potassium ingestion.12

The New England Journal of Medicine study evaluated 10,709 people over an 8.8-year period and found that:

  • Compared to those with the lowest urinary level of sodium excretion, people with the highest level of urinary sodium excretion were 60% more likely to suffer a cardiovascular event.
  • Those with the highest potassium urinary excretion compared with the lowest potassium excretion were 31% less likely to suffer a cardiovascular event defined as a fatal or nonfatal heart attack or stroke.
  • Patients with the highest to lowest sodium-to-potassium urinary excretion ratio (more sodium, less potassium) were 62% more likely to suffer a cardiovascular event.
  • With each unit increase in the sodium-to-potassium excretion ratio (more sodium and less potassium), cardiovascular risks increased 24%.

These data on cardiovascular risks are based on meticulous research. This represents powerful evidence about the deadly impact of excess sodium intake and less-than-optimal ingestion of potassium.

Yet it was largely overlooked by the media, and I fear much of the public.

The take home lesson is for most people to reduce sodium (salt) intake and ensure they are obtaining adequate potassium.

Stroke and heart attack remain leading causes of disability and death despite a wealth of accumulated knowledge.13,14

The encouraging news is that many manageable cardiovascular risk factors have been identified. The disappointing aspect is most people fail to aggressively correct their vulnerabilities towards atherosclerosis.

We at Life Extension® advocate for people to have an at-home blood pressure monitor to ensure 24-hour blood pressure control.

We also urge readers to have comprehensive blood tests to identify risk factors before they suffer a heart attack or stroke.

The 2022 study published in the New England Journal of Medicine strongly confirms what was identified decades ago about the lethal effects of excess sodium and insufficient potassium.

For longer life,

For Longer Life

William Faloon

Highest in Potassium

TOP 10 FOODS

4,700 mg of Potassium = 100% of the Daily Value (%DV)

Highest in Sodium

TOP 10 FOODS

2,300 mg of Sodium = 100% of the Daily Value (%DV)

Beet greens

28% DV (1,309 mg) per cup

39 calories

Table Salt

101% DV (2,325 mg) per tsp

0 calories

Salmon

23% DV (1,068 mg) per 6 oz fillet

309 calories

Cured Ham

91% DV (2,100 mg) per cup

249 calories

Large White Beans

21% DV (1,004 mg) per cup

249 calories

Ham and Egg Biscuit

86% DV (1,989 mg) per item

424 calories

Avocados

21% DV (975 mg) per avocado

322 calories

Pickled Cucumber

81% DV (1,872 mg) per cup

17 calories

Potatoes

20% DV (926 mg) in a medium potato

161 calories

Sunflower Seeds (Dry Roasted)

74% DV (1,706 mg) per oz

155 calories

Acorn Squash

19% DV (896 mg) per cup cooked

115 calories

Clams

44% DV (1,022 mg) per 3 oz serving

126 calories

Milk

16% DV (732 mg) per 16 oz glass

205 calories

Canned Beans (with Added Salt)

38% DV (880 mg) per cup

296 calories

White Button Mushrooms

12% DV (555 mg) per cup cooked

44 calories

French Bread

36% DV (837 mg) per slice

378 calories

Bananas

11% DV (537 mg) per cup sliced

134 calories

Teriyaki Sauce

28% DV (640 mg) per tbsp

32 calories

Tomato

11% DV (523 mg) per cup cooked

43 calories

Grated Parmesean

22% DV (512 mg) per oz

119 calories

References

  1. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations . 3rd ed. Boston: Butterworths Copyright © 1990, Butterworth Publishers, a division of Reed Publishing.; 1990.
  2. Okayama A, Okuda N, Miura K, et al. Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study. BMJ Open.2016;6(7):e011632.
  3. Geleijnse JM, Witteman JCM, Stijnen T, et al. Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study. European Journal of Epidemiology.20072007/11/01;22(11):763-70.
  4. Cook NR, Obarzanek E, Cutler JA, et al. Joint effects of sodium and potassium intake on subsequent cardiovascular disease: the Trials of Hypertension Prevention follow-up study. Arch Intern Med.2009Jan 12;169(1):32-40.
  5. Khaw KT, Barrett-Connor E. Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens. Am J Hypertens.1990Jun;3(6 Pt 1):505-11.
  6. Dietz R, Schomig A, Rascher W, et al. Partial replacement of sodium by potassium in the diet restores impaired noradrenaline inactivation and lowers blood pressure in stroke-prone spontaneously hypertensive rats. Clin Sci (Lond).1981Dec;61 Suppl 7:69s-71s.
  7. Umesawa M, Iso H, Date C, et al. Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer Risks. Am J Clin Nutr. 2008Jul;88(1):195-202.
  8. Yang Q, Liu T, Kuklina EV, et al. Sodium and potassium intake and mortality among US adults: prospective data from the Third National Health and Nutrition Examination Survey. Arch Intern Med.2011Jul 11;171(13):1183-91.
  9. Arbeit ML, Nicklas TA, Berenson GS. Considerations of dietary sodium/potassium/energy ratios of selected foods. J Am Coll Nutr.1992Apr;11(2):210-22.
  10. Langford HG. Sodium-potassium interaction in hypertension and hypertensive cardiovascular disease. Hypertension.1991;17(1_supplement):I155.
  11. Willey J, Gardener H, Cespedes S, et al. Dietary Sodium to Potassium Ratio and Risk of Stroke in a Multiethnic Urban Population: The Northern Manhattan Study. Stroke.2017Nov;48(11):2979-83.
  12. Ma Y, He FJ, Sun Q, et al. 24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk. N Engl J Med.2022Jan 20;386(3):252-63.
  13. Available at: https://www.cdc.gov/chronicdisease/resources/publications/factsheets/heart-disease-stroke.htm . Accessed May 22, 2023.
  14. Available at: https://www.cdc.gov/vitalsigns/million-hearts/index.html . Accessed May 24, 2023.