Life Extension Magazine®

Man and woman sitting in th grass enjoying sliced watermelon

Safely Manage Blood Sugar Levels

Scientists have identified plant-derived ingredients and minerals that can reduce blood glucose levels and improve insulin sensitivity.

Scientifically reviewed by: Dr. Gary Gonzalez, MD, in August 2023. Written by: Erin Davis, MS, RDN, CDCES.

Over 11% of Americans have type II diabetes and 38% have prediabetes.1

Prediabetes is a serious health condition, in which blood sugar is higher than normal but lower than the diabetic threshold.2

Some people argue that the term "prediabetes" be abolished.

That's because elevated glucose levels can increase the risk of vascular disease, eye conditions, nerve damage, dementia, and kidney disease before full-blown type II diabetes manifests.3

But diabetes can be prevented by reducing blood glucose levels before they get too high.4

Unfortunately, glucose-lowering drugs are usually prescribed only after diabetes has been diagnosed.

It doesn't have to be this way. Scientists have discovered several plant-derived ingredients and minerals that can safely reduce blood glucose levels and improve insulin sensitivity.

Promote Healthy Glucose Levels

Insulin is a hormone responsible for regulating glucose. With age,5 poor diet, or a sedentary lifestyle, insulin resistance—the inability to properly use insulin—can develop.6

Insulin resistance can lead to elevated blood glucose levels and type II diabetes.6

In people with prediabetes, lowering blood sugar can reduce the risk of developing diabetes.7 In those who are already diabetic, managing glucose levels can reduce the risk of developing diabetic complications.8

Improving diet and increasing physical activity can help control glucose levels.6,9 Scientists have also identified several plant-derived ingredients that promote healthy blood glucose levels.

They include:

  • Cinnamon,
  • Chromium,
  • Amla,
  • Shilajit, and
  • Iodine-rich seaweed.

Cinnamon Reduces Glucose

Researchers have found that a water-soluble form of cinnamon can help lower blood sugar.

Cinnamon polyphenols help activate our cells' glucose detection systems, which helps them maintain already-healthy blood glucose levels.10,11

Findings of a meta-analysis and systematic review of 16 clinical trials suggest the efficacy of cinnamon supplementation in supporting blood sugar levels, and healthy lipid profile.12

In a clinical study of people with elevated blood glucose, participants were randomized to receive 500 mg of water-soluble extract of cinnamon or a placebo. After 2 months results showed:11

  • Lowered fasting insulin and glucose (lower insulin indicates improved glucose control)
  • Reduced total cholesterol and LDL ("bad") cholesterol
  • Improved insulin sensitivity.

Another clinical study enrolled participants with type II diabetes. Participants were randomized into four groups, two intervention groups (with BMI greater than 27 and less than 27) and 2 placebo (with BMI greater than 27 and less than 27).

Both intervention groups received 500 mg of cinnamon bark powder for 3 months. After 3 months, results showed that cinnamon improved body fat percentage, body mass index, and lipid profiles in people with type II diabetes. Results were more promising in patients with higher BMI at baseline.13

A preclinical study showed that water-soluble cinnamon extract increased the production of glucose transport molecules known as GLUT4. These allow cells to take up glucose from the blood when insulin is present.14,15

Without enough effective GLUT4 transporters, blood glucose can increase, causing insulin resistance and potentially damage to the tissues.16,17

Additional preclinical research revealed that cinnamon may activate and increase the production of metabolic sensors called PPARs,18 which mimic the action of some antidiabetic drugs18,19 Increased expression of PPARs promotes insulin sensitivity, improving glucose uptake and lowering blood sugar.20

Chromium Fights High Glucose

Chromium is a trace mineral.21,22 Cell and animal study model studies suggest that chromium might improve insulin sensitivity.23

In one observational study, lower levels of chromium were associated with diabetes and prediabetes.24

A systematic review and meta-analysis of 25 randomized controlled trials of chromium supplementation in people with diabetes found that oral chromium significantly:25

  • Improved blood sugar levels,
  • Lowered HbA1c (average blood glucose),
  • Raised HDL ("good") cholesterol, and
  • Lowered triglycerides.

It has been proposed that chromium may work by activating GLUT4 and enhancing insulin transport of glucose into the cells, improving response to elevated blood glucose levels.26

An observational study concluded that the odds of having type II diabetes were lower in those that had consumed supplements with chromium.27

In a human trial of diabetics whose blood sugar parameters were insufficiently maintained on prescription medication, participants were randomized to receive, daily, 200 micrograms of chromium combined with the natural product shilajit and the ayurvedic herb amla, or a placebo, in addition to medication. After 60 days, the treatment group had significantly greater improvements in fasting and post-prandial glucose levels, compared to placebo.28

What You Need to Know

Promote Healthy Glucose Levels

  • As people age, many develop insulin resistance and elevated glucose, often leading to prediabetes and type II diabetes.
  • A water-soluble cinnamon extract has been shown to reduce blood glucose and increase insulin sensitivity.
  • The mineral chromium has been shown to improve fasting blood sugar and HbA1c (average blood glucose) levels.
  • Amla and shilajit each have demonstrated antioxidant, anti-inflammatory, and glucose-lowering effects.
  • Iodine-rich brown seaweed can stop the conversion of starches into glucose, lowering blood sugar and increasing insulin sensitivity.
  • These ingredients can help maintain healthy glucose levels and prevent the damage elevated glucose can do.

Shilajit’s Properties

A Himalayan nutrient that has been used for centuries, shilajit is rich in fulvic acid. Fulvic acid is an organic compound that may contribute to shilajit's medicinal properties.29,30

Shilajit has traditionally been used to manage diabetes30 and gastrointestinal conditions (such as gastritis, and ulcers),30-32 and muscular strength.33

Preclinical data reveal that shilajit may also reduce insulin resistance.34

In a clinical trial, 90 diabetic patients were randomized to receive 500mg of shilajit twice daily or a placebo. After 3 months improvements in the blood sugar levels were observed.35

Amla’s Benefits for Diabetes

Amla, also known as Indian gooseberry, is an herb that has been shown to lower blood glucose in animals and humans with diabetes.36,37

A source of bioactive compounds, amla has been shown to have antimicrobial, antioxidant, and anti-inflammatory properties.38

In people with type II diabetes, one study showed that, compared to a placebo, taking a combination of chromium, amla, and shilajit with current medication resulted in better fasting and post-meal glucose levels.28

Seaweed Aids Glucose Control

Seaweed is an excellent source of iodine,39 a trace element that is vital to metabolic control and thyroid hormone synthesis.40 Clinical studies have shown that consuming brown seaweed can reduce glucose levels.41

Seaweed is thought to work by blocking enzymes required for the conversion of starches into glucose in the gastrointestinal tract, resulting in less glucose being absorbed into the bloodstream.42,43

Clinical trials have shown that brown seaweed extract can:44-46

  • Lower fasting glucose,
  • Increase insulin sensitivity,
  • Lower HbA1c levels, and
  • Improve post-meal cognitive function.

In one preclinical study, brown seaweed was found to improve diet-induced metabolic diseases, such as diabetes, and reduce insulin resistance.47

A systematic review and meta-analysis of human trials was conducted to assess the effects of brown seaweed on plasma glucose levels. The participants were either at high risk of diabetes, had diabetes, or had healthy blood glucose levels. It was concluded that brown seaweed and its extracts positively affect plasma glucose levels and have the potential for managing high blood sugar.41

Seaweed, amla, shilajit, chromium, and cinnamon can help support healthy glucose levels, protecting against the damage of high blood sugar.

Summary

The elevated glucose levels seen in prediabetes and diabetes increase the risk for heart disease, dementia, nerve damage, and kidney disease.

Cinnamon, chromium, amla, shilajit, and seaweed can help reduce high glucose levels, potentially preventing complications related to high blood sugar.

Anyone can benefit from maintaining healthy blood glucose levels, even people without diabetes or prediabetes.

If you have any questions about the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.

References

  1. Available at: https://www.cdc.gov/diabetes/data/statistics-report/ . Accessed May, 16, 2023.
  2. Cai X, Zhang Y, Li M, et al. Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis. BMJ.2020 Jul 15;370:m2297.
  3. Mouri M, Badireddy M. Hyperglycemia. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2023, StatPearls Publishing LLC.; 2023.
  4. Shubrook JH, Chen W, Lim A. Evidence for the Prevention of Type 2 Diabetes Mellitus. J Am Osteopath Assoc.2018 Nov 1;118(11):730-7.
  5. Shou J, Chen PJ, Xiao WH. Mechanism of increased risk of insulin resistance in aging skeletal muscle. Diabetol Metab Syndr.2020;12:14.
  6. Available at: https://www.cdc.gov/diabetes/basics/insulin-resistance.html . Accessed May, 16, 2023.
  7. Available at: https://www.cdc.gov/diabetes/basics/prediabetes.html . Accessed May, 16, 2023.
  8. Available at: https://www.cdc.gov/chronicdisease/programs-impact/pop/diabetes.htm . Accessed May, 16, 2023.
  9. American Diabetes Association Professional Practice C. 5. Facilitating Behavior Change and Well-being to Improve Health Outcomes: Standards of Medical Care in Diabetes-2022. Diabetes Care.2022 Jan 1;45(Suppl 1):S60-S82.
  10. Kizilaslan N, Erdem NZ. The Effect of Different Amounts of Cinnamon Consumption on Blood Glucose in Healthy Adult Individuals. Int J Food Sci. 2019;2019:4138534.
  11. Anderson RA, Zhan Z, Luo R, et al. Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose. J Tradit Complement Med.2016 Oct;6(4):332-6.
  12. Zhou Q, Lei X, Fu S, et al. Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review. Front Physiol.2022;13:960580.
  13. Zare R, Nadjarzadeh A, Zarshenas MM, et al. Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial. Clin Nutr.2019 Apr;38(2):549-56.
  14. Cao H, Polansky MM, Anderson RA. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys.2007 Mar 15;459(2):214-22.
  15. Silva ML, Bernardo MA, Singh J, et al. Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review. Nutrients. 2022 Jul 5;14(13).
  16. Singh VP, Bali A, Singh N, et al. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol.2014 Feb;18(1):1-14.
  17. Vargas E PV, Carrillo Sepulveda MA. Physiology, Glucose Transporter Type 4. StatPearls Publishing.2022.
  18. Sheng X, Zhang Y, Gong Z, et al. Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors. PPAR Res.2008;2008:581348.
  19. Miyazaki Y, Mahankali A, Matsuda M, et al. Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care.2001 Apr;24(4):710-9.
  20. Medagama AB. The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. Nutr J.2015 Oct 16;14:108.
  21. Sciencees NAo. Geochemistry and the Environment: Volume I: The Relation of Selected Trace Elements to Health and Disease. Washington, DC: The National Academies Press; 1974.
  22. Available at: https://www.merckmanuals.com/home/disorders-of-nutrition/minerals/chromium-deficiency . Accessed May, 16, 2023.
  23. Available at: https://lpi.oregonstate.edu/mic/minerals/chromium . Accessed May, 16, 2023.
  24. Chen S, Jin X, Shan Z, et al. Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study. Nutrients.2017 Mar 17;9(3).
  25. Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther.2014 Jun;39(3):292-306.
  26. Hua Y, Clark S, Ren J, et al. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem.2012 Apr;23(4):313-9.
  27. McIver DJ, Grizales AM, Brownstein JS, et al. Risk of Type 2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements. J Nutr. 2015 Dec;145(12):2675-82.
  28. Biswas T, Polley G, Pandit S, et al. Effects of adjunct therapy of a proprietary herbo-chromium supplement in type 2 diabetes: A randomized clinical trial. Int J Diab Dev Ctries.2010;30(3):153-61.
  29. Stohs SJ. Safety and efficacy of shilajit (mumie, moomiyo). Phytother Res. 2014 Apr;28(4):475-9.
  30. Yaqoob Z. Review on Shilajit Used in Pakistani Traditional Medicine. Modern Journal of Medicine and Biology Mod J Med Biol.2021.
  31. Agarwal SP, Khanna R, Karmarkar R, et al. Shilajit: a review. Phytother Res.2007 May;21(5):401-5.
  32. Schepetkin IA, Xie G, Jutila MA, et al. Complement-fixing activity of fulvic acid from Shilajit and other natural sources. Phytother Res. 2009 Mar;23(3):373-84.
  33. Keller JL, Housh TJ, Hill EC, et al. The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels. J Int Soc Sports Nutr.2019 Feb 6;16(1):3.
  34. Ghezelbash B, Shahrokhi N, Khaksari M, et al. Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease. Chin J Integr Med.2022 Jun;28(6):531-7.
  35. Gupta V, Keshari BB, Tiwari SK, et al. A comparative study of Shilajatu and Asanadi Ghana Vati in the management of Madhumeha w.s.r. to type-2 diabetes mellitus. Ayu.2016 Apr-Jun;37(2):120-4.
  36. D'Souza J J, D'Souza P P, Fazal F, et al. Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action. Food Funct.2014 Apr;5(4):635-44.
  37. Kapoor MP, Suzuki K, Derek T, et al. Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study. Contemp Clin Trials Commun.2020 Mar;17:100499.
  38. Khalid M, Sofi SA, Makroo HA, et al. Insight about the biochemical composition, postharvest processing, therapeutic potential of Indian gooseberry (amla), and its utilization in development of functional foods-A comprehensive review. J Food Biochem.2022 Mar 27:e14132.
  39. Available at: https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/ . Accessed 03/29/2023.
  40. Song E, Park MJ, Kim JA, et al. Impact of urinary iodine concentration on blood glucose levels and blood pressure: a nationwide population-based study. Eur J Nutr.2022 Sep;61(6):3227-34.
  41. Vaughan K, Ranawana V, Cooper D, et al. Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis. Nutr Rev.2022 Apr 8;80(5):1194-205.
  42. Lordan S, Smyth TJ, Soler-Vila A, et al. The alpha-amylase and alpha-glucosidase inhibitory effects of Irish seaweed extracts. Food Chem. 2013 Dec 1;141(3):2170-6.
  43. Zhang J, Tiller C, Shen J, et al. Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosumThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products. Canadian Journal of Physiology and Pharmacology.2007;85(11):1116-23.
  44. Paradis ME, Couture P, Lamarche B. A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Appl Physiol Nutr Metab.2011 Dec;36(6):913-9.
  45. Derosa G, Cicero AFG, D'Angelo A, et al. Ascophyllum nodosum and Fucus vesiculosus on glycemic status and on endothelial damage markers in dysglicemic patients. Phytother Res.2019 Mar;33(3):791-7.
  46. Haskell-Ramsay CF, Jackson PA, Dodd FL, et al. Acute Post-Prandial Cognitive Effects of Brown Seaweed Extract in Humans. Nutrients.2018 Jan 13;10(1).
  47. Murakami S, Hirazawa C, Ohya T, et al. The Edible Brown Seaweed Sargassum horneri (Turner) C. Agardh Ameliorates High-Fat Diet-Induced Obesity, Diabetes, and Hepatic Steatosis in Mice. Nutrients.2021 Feb 8;13(2).