Age Reversal Update

Each year I dedicate enormous time to a scientific conference titled Revolution Against Aging and Death.

The abbreviation for this event is “RAADfest.”

It is presented by a charitable group called the Coalition for Radical Life Extension.

The inspiration for RAADfest occurred in 2015, as a confluence of biomedical advances made clear that it may be possible to turn degenerative aging into a manageable condition in our lifetime.

Findings from small human studies that I help organize and fund, show improvements in clinical measures (such as blood pressure and joint function) and aging biomarkers (such as DNA health and inflammatory indicators).

I’ve self-experimented with many of these age reversal interventions.

So far, objective measures indicate that I may be growing biologically younger. The same may be true of most of the volunteers who participated in the proof-of-concept clinical trials.

The results of these studies are so impressive that a new charity was established in 2019 to fund a human age reversal trial that is unparalleled in the history of medical science.

The objective of this study is to carefully measure the effects of a combination of regenerative approaches that include:

1. AMPK activation,
2. Removal of senescent cells (using senolytics),
3. Suppression of excess mTOR,
4. Restoration of NAD+,
5. Additional approaches being explored now.

This article will summarize a few of the major announcements made at RAADfest 2019. These include published results from a clinical trial that resulted in an unprecedented 2.5-year average reversal of biological age as measured by epigenetic aging clocks!

None of this would be possible without your purchases of Life Extension^® nutrient formulas and laboratory tests.

Proceeds from these sales support scientific endeavors that have little or no commercial value but may enable substantive increases in healthy longevity to benefit all of humanity.

RAADfest 2019 may go down in the history books as a major inflection point in our battle against and victory over degenerative aging.

More than 260 people enrolled in a new project called the Vitality in Aging Longitudinal Study. This represented 25% of the 1,000 or so RAADfest 2019 attendees!

Even more would have enrolled if the Vitality in Aging research group had the time to expand its staff to accommodate the tremendous interest shown.

People had to be turned away from the clinic established in the hotel because the resources were not sufficient to enroll everyone who was eager to join.

The Vitality in Aging Longitudinal Study will enable meticulous measures of regenerative interventions, including the stair-step approach to biological age control outlined below.

Many more are expected to enroll as new clinical study sites open throughout the United States and beyond.

Human Age Reversal Demonstrated!

Unparalleled results from a published clinical trial were presented at RAADfest 2019.

The findings reveal a 2.5-year reversal in biological age markers in healthy men aged 51-65!

This study was conducted by Dr. Greg Fahy’s Intervene Immune group in collaboration with researchers from Stanford University and UCLA. This one-year treatment protocol showed:¹

1. Regenerated thymic structure,

2. Improved immune function with signs of increased cancer protection,

3. Improved prostate cancer markers (PSA and percent free PSA),

4. Regenerative effects on kidney function and bone marrow, and

5. 2.5 years of age reversal, on average, as measured by four different DNA methylation tests.

Biological age was assessed by multiple epigenetic aging clocks. Dr. Steve Horvath from UCLA, the original developer of this technology, who is considered to be the world’s foremost expert in its use, was one of the investigators in this trial.

Measurement of DNA methylation patterns may be the most accurate biomarker test to asses biological age and can be a strong predictor of future healthspan and lifespan.

The interventions used by Dr. Fahy’s group were individualized doses of metformin, DHEA, and human growth hormone.

The rationale for the study is that growth hormone is known to regenerate the thymus gland, which is vital for youthful immune responses. Downsides to growth hormone are insulin resistance and a potential to stimulate proliferation of malignant cells, but both problems were apparently contained by the protocol employed.

By combining metformin and DHEA with growth hormone for just one year, the benefits of growth hormone (such as systemic tissue regeneration) occurred with no significant side effects and the unexpected side benefit of an average of 2.5 years of biological age reversal as measured by DNA methylation clocks.

Before and after MRI tests validated the regeneration of thymic structure. (These MRI scans were funded in part by our Life Extension^® group.)

And breaking news I just learned is that the study subjects that demonstrated 2.5 years of age reversal continue to demonstrate rejuvenating signs after the one year of low-dose growth hormone was discontinued.

Many of you already take DHEA as well as AMPK-activating compounds like metformin or AMPK-activating nutrients like Gynostemma pentaphyllum.

Dr. Fahy’s group at Intervene Immune is now launching an expanded study of this longevity protocol in Southern California and exploring ways to make treatment widely available and affordable. Additional information about their work appears on page 65 of this month’s issue.

My goal is to enable readers of Life Extension^® magazine to gain access to this new age reversal intervention at ultra-low pricing as part of a large new study group managed by Intervene Immune.

Other potential longevity approaches were introduced at RAADfest 2019.

The Vitality in Aging Longitudinal Study looks forward to measuring the efficacy of these interventions and reporting the results to rapidly advance the science.

New Human Rejuvenation Trial

Those who enrolled in the Vitality in Aging Longitudinal Study are being carefully screened to meet eligibility criteria to enroll in the:

Vitality in Aging Interventions Trial

This clinical trial aims to induce statistically significant and meaningful age reversal in only 12 months. It will entail very close physician oversight and precise, careful introduction of the regenerative interventions.

Funding has been secured to study 40-50 people using multiple therapies and in-depth biomarkers to ascertain the degree of age reversal that may be occurring.

The interventions that will be introduced are represented by the first four steps in the image on the facing page to the left. Later Vitality in Aging studies will include newer interventions as cutting-edge research continues to provide more healthy longevity options.

New Donations Received

Right before my keynote RAADfest presentation, one of our supporters let me know that he was not happy about the progress made with a new charity I established called the Human Age Reversal Project.

Specifically, his concern was that as of October 1, 2019, we had only raised $395,000.

He made a new donation of more than $200,000. This, along with other donations received to date, brings our total to more than $675,000.

All Human Age Reversal Project donations are placed in an interest-bearing brokerage account. I expect this to grow much higher as more people understand the ramifications of this research for themselves and all of humanity.

I provided hundreds of thousands of dollars to launch the Vitality in Aging Longitudinal Study in 2019 and will continue to support it.

For the Vitality in Aging Interventions Trial, we will need new donations to expand beyond the first 15 months.

I ask that you help support the Human Age Reversal Project. We are accelerating age reversal initiatives and every penny goes towards the research; there are no salaries or fixed overhead costs!

Donation information is to the right:

The Medical Clinic at RAADfest

The medical clinic set up at RAADfest was filled with people seeking to enroll in the Vitality in Aging (VIA) Longitudinal Study.

Many who wanted to join could not because the lines were too long.

While huge resources were spent to open the Vitality in Aging Longitudinal Study clinic, the staff was unable to handle the unexpectedly large response.

Another temporary enrollment center was set up in Phoenix, Arizona, in November 2019 so that some of those who want to join this study could do so.

The Vitality in Aging research group spent three months after RAADfest 2019 processing applications, baseline clinical data, the many different blood samples taken, and enrolling more study subjects.

From the group of over 300 enrollees in the Vitality in Aging Longitudinal Study, an initial 40-50 will be selected who meet the eligibility criteria to qualify for the Vitality in Aging Interventions Study.

Just to clarify, before it can be determined if you meet the eligibility criteria to join the Vitality in Aging Interventions Study, you first need to enroll in the Vitality in Aging Longitudinal Study so your data can be collected and analyzed.

My RAADfest keynote talk introduced and explained the differences between these two human age reversal studies.

To view my 55-minute presentation (with new slides added), log on to the home page of the Age Reversal Network: www.age-reversal.net

How to Enroll in the Longitudinal Study

The Vitality in Aging Longitudinal Study is modeled after the famous Framingham Heart Study that enabled scientists to identify risk factors that cause heart attack and stroke.

Copied in these pages are Power Point slides I used at RAADfest to describe the Framingham Heart Study and how many lives were saved.

The plan is to rapidly identify risk factors that cause accelerated aging and what lifestyles and interventions (such as senolytic therapy) can reverse aging biomarkers.

Vitality in Aging Longitudinal Study sites are expected to open in most major cities. This will provide convenient access to people interested in joining a team effort to defeat aging.

The goal is to have qualified volunteer doctors in most major metropolitan areas, or you can travel to one of the study sites expected to open in Southern California, South Florida, Las Vegas, and Idaho.

The first step for those interested in participating in either of these studies is to have an Age Management Blood Test Panel. The results enable the research group and you to determine if you best qualify for either:

Vitality in Aging Longitudinal Study

Or

Vitality in Aging Interventions Trial

The retail price of the individual tests included in this new Age Management Blood Test Panel is around $3,000.

It is being made available for a limited time for $495, which includes your registration in the Vitality in Aging Longitudinal Study.

For those who utilize the Male or Female Blood Test Panels from LifeExtension^®, the new Age Management Panel can be used to take its place with many more tests included.

The individual tests in the new Age Management Blood Test Panel can be viewed on the next page.

To order this blood test and enroll in the Vitality in Aging Longitudinal Study electronically, please log on to: VitalityInAging.org/sign-up

If you don’t want this blood test now, but want to be kept informed about the studies for your future consideration, please register your name and contact information at: VitalityInAging.org

By enrolling in the Longitudinal Study or registering your potential interest, you will be kept informed about new and current research initiatives spearheaded by the Vitality in Aging research group and local meetings.

To receive email updates about results from regenerative medicine trials, as well as about how you can gain affordable access to many of the interventions, you can join a private association called the Age Reversal Network at no cost by logging on to: https://age-reversal.net/join

Concluding Remarks

The Vitality in Aging research groups are making headway in measuring the efficacy of currently available regenerative interventions.

The goal is to identity which combinations of interventions are most effective in inducing meaningful human age reversal.

By enrolling in the Vitality in Aging Longitudinal Study, you obtain baseline measures of your state of health and can track improvements that occur in response to whichever rejuvenation protocol you choose (or do NOT choose).

Data sets will be compared to enable rapid identification of the most robust approaches to age reversal available today!

I look forward to keeping you posted on new plans for transforming emerging scientific findings into practical steps to improve your health and longevity.

To receive email updates about results from regenerative medicine trials, as well as about how you can gain affordable access, you can join a private association called the Age Reversal Network at no cost by logging on to: https://age-reversal.net/join

Note the Age Reversal Network is entirely separate from the Life Extension^® group I founded in 1977 (and first published in 1980).

You can read a description of the Age Reversal Network below.

For longer life,

William Faloon

Co-Founder,
Coalition for Radical Life Extension
Age Reversal Network

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References

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3. Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999 May;106(5):506-12.
4. Duarte PO, Duarte MGF, Pelichek A, et al. Cardiovascular risk factors and inflammatory activity among centenarians with and without dementia. Aging Clin Exp Res. 2017 Jun;29(3):411-7.
5. Garbers C, Kuck F, Aparicio-Siegmund S, et al. Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle. 2013 Nov 1;12(21):3421-32.
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8. Tabas I, Williams KJ, Boren J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation. 2007 Oct 16;116(16):1832-44.
9. Masson W, Siniawski D, Lobo M, et al. Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression. Arq Bras Cardiol. 2015 Jul;105(1):11-9.